Recommended Set

16. Animal care and monitoring Report any expected or unexpected adverse events. explanation

16a Describe any interventions or steps taken in the experimental protocols to reduce pain, suffering, and distress.
16b Report any expected or unexpected adverse events.
16c Describe the humane endpoints established for the study, the signs that were monitored, and the frequency of monitoring. If the study did not have humane endpoints, state this.
Explanation
Examples

Reporting adverse events allows other researchers to plan appropriate welfare assessments and minimise the risk of these events occurring in their own studies. If the experiment is testing the efficacy of a treatment, the occurrence of adverse events may alter the balance between treatment benefit and risk [1].

Report any adverse events that had a negative impact on the welfare of the animals in the study (e.g. cardiovascular and respiratory depression, CNS disturbance, hypothermia, reduction of food intake). Indicate whether they were expected or unexpected. If adverse events were not observed, or not recorded during the study, explicitly state this.

 

References

  1. Muhlhausler BS, Bloomfield FH and Gillman MW (2013). Whole Animal Experiments Should Be More Like Human Randomized Controlled Trials. PLoS Biol. doi: 10.1371/journal.pbio.1001481